Novel conformations of erythromycin antibiotics: the conformational analysis of erythromycin A and (9S)-9-hydroxy-9-deoxoerythromycin A by n.m.r. spectroscopy
Abstract
1 H and 13C N.m.r. spectroscopy combined with molecular modelling has been used to characterise novel ‘folded-in’ lactone ring conformations of erythromycin A (1) and its (9S)-9-deoxo analogue (2) in CDCl3 solution.