Asymmetric intramolecular conjugate addition of amines to chiral vinyl sulphoximides. Total synthesis of (R)-(+)- and (S)-(–)-carnegine
Abstract
The chiral vinyl sulphoximides (3a) and (3b) upon treatment with base, undergo cyclization to give chiral isoquinolines which were converted in to (R)-(+) and (S)-(–)-Carnegine.