Aqueous solutions containing amino acids and peptides. Part 17.—Pairwise enthalpic coefficients for the interaction of N-acetyl-L-phenylalaninamide with some N-acetylamino acid amides at 25 °C

Abstract

Enthalpies of dilution of N-acetyl-L-phenylalaninamide and equimolal solutions of this with N-acetylglycinamide, N-acetyl-L-alaninamide, N-acetyl-L-valinamide and N-acetyl-L-leucinamide have been determined using microcalorimetry. The results obtained were used to calculate the pairwise enthalpic coefficients for both like–like (homotactic) and like–unlike (heterotactic) solute interactions. These were then used with a group-additivity approach, which works well for these systems, to obtain information on the interaction of defined groups with each other.