Stereo- and enantio-controlled synthesis of chiral intermediates for the total synthesis of thienamycin and related β-lactam antibiotics from 3-hydroxybutyrates
Abstract
The synthesis of (1′R,3S,4S)-and (1′R,3S,4R)-3-(1′-t-butyldimethylsilyoxyethyl)-4-hydroxymethyl-2-azeidinone from ethyl(S)-3-hydroxybutyrate is reported.