Synthesis of galanin, a new gastrointestinal polypeptide

Abstract

A new gastrointestinal polypeptide, galanin, which consists of 29 amino acids, was synthesized using the trifluoromethanesulphonic acid deprotecting procedure: two new amino acid derivatives, Trp(Mts)[Mts =Nⁱ mesitylene-2-sulphonyl] and Asp(OChp)[Chp =β-cycloheptyl], were employed for this synthesis to suppress possible side reactions, i.e., indole-alkylation and succinimide formation respectively; the synthetic peptide exhibited contractile activity in isolated rat ileum and hyperglycemic activity in dogs.