Structural features that affect the binding of teicoplanin, ristocetin A, and their derivatives to the bacterial cell-wall model N-acetyl-D-alanyl-D-alanine

Abstract

Studies with the title antibiotics have confirmed that the N-terminal amino groups of such glycopeptides play a major rôle in binding to N-acetylD-alanyl-D-alanine; one sugar is found to affect free energy of binding but the other sugars and fatty acid groups attached to the aglycones have more uncertain rôles.