(±)-Corydalic acid methyl ester (1), a 3-arylisoquinoline alkaloid, was efficiently synthesized from the corresponding protoberberine alkaloid, corysamine (5)via a biogenetic route.
M. Hanaoka, S. Yoshida and C. Mukai, J. Chem. Soc., Chem. Commun., 1984, 1703 DOI: 10.1039/C39840001703
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