Mouse epiderma growth factor (EGF), which consists of 53 amino acids with 3 disulphide bridges, was synthesized in a conventional manner by assembling 15 peptide fragments of established purity followed by thioanisole-mediated deprotection with trifeluoromethanesulphonic acid in trifuoroacetic acid and subsequent air oxidation.
H. Yajima, K. Akaji, N. Fujii, K. Hayashi, K. Mizuta, M. Aono and M. Moriga, J. Chem. Soc., Chem. Commun., 1984, 1103 DOI: 10.1039/C39840001103
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