Synthesis of (R)-4-hydroxy-2-(1,3-dithian-2-ylmethyl)-cyclopent-2-en-1-one, a chiral prostaglandin E2 synthon, from D-glucose
Abstract
The transformation of D-glucose to (R)-4-hydroxy-2-(1,3-dithian-2-ylmethyl)cyclopent-2-en-1-one (1), a potential chiral synthon for prostaglandin E2 and its analogues, is described.