Biosynthesis of viridicatumtoxin, a mycotoxin from Penicilium expansum
Abstract
Incorporation of sodium [1-13C]-, [2-13C]-, [1,2-13C2]-, and [1-13C, 18O]-acetate, sodium [1,2,3-13C3]- malonate, and (2S)-[Me-13C]methionine as well as sodium hydrogen[14C]carbonate and sodium[1-14C]pyruvate into viridicatumtoxin, a metabolite from Penicillium expansum, indicates its formation by a mixed polyketide–terpenoid biosynthetic pathway.