Metallation and metal–halogen exchange reactions of imidazoles
Abstract
Some reactions (reagents in parentheses) are reported of 1-ethoxymethyl-2-phenylthioimidazol-5-yl-lithium {Me2S2, Ph2S2, [(EtO)2CHCH2]2S2}, 1-ethoxymethyl-5-methylthio-2-phenylthioimidazol-4-yl-lithium (Me2S2, HCONMe2, CO2), 4, 5-dibromo-1-ethoxymethyl-imidazol-2-yl-lithium (Me2S2, Ph2S2), and 2-substituted derivatives of 4-bromo-1-ethoxymethylimidazol-5-yl-lithium (e.g. with Me2S2), prepared by metallation or metal halogen exchange reactions.