Photocyclisation of the enamide (1) followed by stereoselective functionalisation of the cis-lactam (4c) completed the first total synthesis of the alkaloids, (±)-corynoline (7e), (±)-12-hydroxycorynoline (7d), and (±)-11-epicorynoline (7c). Participation of the basic nitrogen in the oxidation with peracid was also suggested.
I. Ninomiya, O. Yamamoto and T. Naito, J. Chem. Soc., Perkin Trans. 1, 1980, 212 DOI: 10.1039/P19800000212
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