Epimeric 6,8-dimethylergolines (VI), (VII), and (IX) have been synthesised from the lactam (IVa) which was prepared by the reaction of the enamine (II) with methacryloyl chloride or methacrylamide. The stereochemistry of costaclavine (VI) has been established by comparison of the n.m.r. spectra of compounds (VI), (VII), (IX) and (X).
I. Ninomiya, T. Kiguchi and T. Naito, J. Chem. Soc., Perkin Trans. 1, 1980, 208 DOI: 10.1039/P19800000208
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