Synthesis and stability of sulphate ester conjugates of monohydroxybenzo[a]-pyrenes in relation to possible benzo[a]pyrene detoxification mechanisms
Abstract
The reaction of 1-, 3-, 7-, and 9-monohydroxy benzo[a]pyrenes with dicyclohexylcarbodi-imide (DCC) and H2SO4 in dimethylformamide yields the corresponding sulphate esters, which are stable in a pH range of 2 to 14 at 37°C.