Acid-catalysed displacement of 7α-methoxy-7β-amino-l-oxacephem (1) with nucleophiles gave the 7α-substituted-7β-amino compounds (5–8), which were converted into the antibiotics (13–16).
Y. Sendo and M. Yoshioka, J. Chem. Soc., Chem. Commun., 1980, 1069 DOI: 10.1039/C39800001069
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