Synthesis of 26,26,26,27,27,27-hexafluoro-25-hydroxyvitamin D3
Abstract
In order to investigate the biological significance of 26-hydroxylation of vitamin D3, 26,26,26,27,27,27-hexafluoro-25-hydroxyvitamin D3 was prepared from 24-tosyloxy-25,26,27-trinorcholest-5-en-3β-yl tetrahydropyranyl ether.