Mercuration reactions of porphyrins: new efficient syntheses of harderoporphyrin and isoharderoporphyrin
Abstract
Treatment with mercury(II) acetate of metal complexes of porphyrins bearing peripherally unsubstituted positions gives the corresponding mercurated derivatives; using the palladium–olefin reaction, this observation is exploited in the synthesis of coproporphyrin III tetramethyl ester (2), harderoporphyrin trimethyl ester (3), and isoharderoporphyrin trimethyl ester (4).