2′,3′-O-Isopropylidene-adenosine, -cytidine, and -guanosine, (2a), (3a), and (4a), respectively react with formaldehyde in ethanol solution to give the corresponding N-ethoxymethyl derivatives, (2b), (3b), and (4b), respectively in good yields.
P. K. Bridson, J. Jiricny, Ö. Kemal and C. B. Reese, J. Chem. Soc., Chem. Commun., 1980, 208 DOI: 10.1039/C39800000208
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