A method for the oxidation of trimethylsilylated amides to the corresponding hydroxamic acids is described. The method utilises aprotic oxidants, based on MoV peroxides and has been demonstrated for the oxidation of a variety of secondary amides. The oxidation is particularly efficient for aromatic amides and has been applied to the synthesis of herbicides of the 2,4-dihydroxybenzoxazinone class.
S. A. Matlin, P. G. Sammes and R. M. Upton, J. Chem. Soc., Perkin Trans. 1, 1979, 2481 DOI: 10.1039/P19790002481
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