Issue 24, 1979

Proof by synthesis that unrearranged hydroxymethylbilane is the product from deaminase and the substrate for cosynthetase in the biosynthesis of uro'gen-III

Abstract

The labile unrearranged hydroxymethylbilane (5) is synthesised unambiguously, is proved to be identical with the product from deaminase acting on porphobilinogen, and is shown to be the substrate for deaminase-free cosynthetase which quantitatively ring-closes (5) with rearrangement to uro'gen-III (7).

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1979, 1155-1158

Proof by synthesis that unrearranged hydroxymethylbilane is the product from deaminase and the substrate for cosynthetase in the biosynthesis of uro'gen-III

A. R. Battersby, C. J. R. Fookes, K. E. Gustafson-Potter, G. W. J. Matcham and E. McDonald, J. Chem. Soc., Chem. Commun., 1979, 1155 DOI: 10.1039/C39790001155

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