Synthesis of 9-deoxa-9,10-dehydroprostaglandin-D2 through reaction of 2-oxatricyclo[3.3.0.04,6]oct-7-en-3-one with a cuprate reagent
Abstract
The prostanoid (10) has been prepared by reaction of the tricyclic lactone (4) with the cuprate reagent (12) to give the acid (5) and subsequent Cope rearrangement of the related aldehyde (6).