The epoxyester (4) reacted with the cuprate reagent (11) in SN′ fashion preferentially to give the lactone (6) which could be readlily converted into prostaglandin-A2.
M. A. W. Finch, T. V. Lee, S. M. Roberts and R. F. Newton, J. Chem. Soc., Chem. Commun., 1979, 677 DOI: 10.1039/C39790000677
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