Issue 16, 1979

Simple and regioselective synthesis of N-substituted pyrimidine-2(1H)-ones and -thiones

Abstract

The di-imines (1), obtained by the reaction of Schiff bases with saturated nitriles, react with ethyl chloroformate and carbon disulphide giving rise to an efficient method for synthesising pyrimidine-2(1H)-ones and -thiones, respectively.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1979, 675-676

Simple and regioselective synthesis of N-substituted pyrimidine-2(1H)-ones and -thiones

J. Barluenga, M. Tomás, V. Rubio and V. Gotor, J. Chem. Soc., Chem. Commun., 1979, 675 DOI: 10.1039/C39790000675

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