N-Methyl inversions should be considered in terms of two half-barriers, ax→ts(increased in piperidine by β-heteroatom substitution) and eq→ts(lowered by β-heteroatoms); this resolves previous controversy and rationalises literature data.
A. R. Katritzky, R. C. Patel and F. G. Riddell, J. Chem. Soc., Chem. Commun., 1979, 674 DOI: 10.1039/C39790000674
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