Carbon-13 nuclear magnetic resonance assignments and biosynthesis of versicolorin A in Aspergillus parasiticus

Abstract

The ¹³C n.m.r. spectrum of versicolorin A has been assingned. The distributions of ¹³C label and of the intact acetate units have been determined from the ¹³C n.m.r. spectra of versicolorin A derived from singly and doubly labelled [¹³C]acetate. The biosynthesis of versicolorin A in relation to that of previously determined C₂₀ anthraquinones and aflatoxin B₁ is discussed. The absolute configuration of versicolorin A is deduced.