Electrophilic bromination of the isoxazole ring proceeds via a stabilized isoxazolium ion, which can undergo an intramolecular cis-addition of a neighbouring benzamido- or carboxylate group to afford bromospirobi-heterocyclic compounds containing the isoxazoline ring, or rearrangement products.
G. S. d'Alcontres, C. Caristi, A. Ferlazzo and M. Gattuso, J. Chem. Soc., Perkin Trans. 1, 1976, 1694 DOI: 10.1039/P19760001694
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