Azabenzocycloheptenones. Part XVIII. Amines and amino-ketones of the tetrahydro-3-benzazepin-1-one series
Abstract
2,3,4,5-Tetrahydro-3-benzazepin-1-one and its 3-benzyloxycarbonyl and 3-methyl derivatives have been synthesised from 2,3,4,5-tetrahydro-3-p-tolylsulphonyl-3-benzazepin-1-one. 2,3,4,5-Tetrahydro-7,8-dimethoxy-3-p-tolylsulphonyl-3-benzazepin-1-one was made by cyclisation of the corresponding glycine in polyphosphoric acid at 20° but all attempts to cyclise N-alkylglycines failed.