Molecular crowding and remote substituent effects in 1-aryltetrahydronaphthalene derivatives
Abstract
Further substitution (X) in the pendant ring of lignans of the 1-aryltetrahydronaphthalene type [e.g.(1)] leads to increased strain in ring B and in the lactone function, as a result of which solvolysis reactions at C(4) are accelerated and the base-catalysed opimerisation at C(2), which occurs readily in the natural precursors, is not observed.