Synthesis of 11-deoxy-10α-hydroxyprostaglandins
Abstract
The β-elimination of the 11-acetoxy-grouping of the aldehyde (2) by ready anion formation at C-12 gives the conjugated aldehyde (3); catalytic hydrogenation of (3), followed by alkylation under equilibrating conditions, allows access to novel prostaglandins, which are isomeric with PGF2α and PGE2.