Cysteinyl residues react with 2-fluoro-3-nitropyridine rapidly and under mild conditions. The c.d. spectra of the resulting chromophoric S-3-nitro-2-pyridyl derivatives have been recorded. The results suggest the application of the reaction to the analytical determination of thiol groups in peptide molecules.
C. Toniolo, D. Nisato, L. Biondi and A. Signor, J. Chem. Soc., Perkin Trans. 1, 1972, 1182 DOI: 10.1039/P19720001182
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