Angular dependence of substituent effects in rigid, bicyclic systems
Abstract
The rates of alkaline hydrolysis of the isomeric ethyl 5,6-epoxybicyclo[2,2,2]octane-2-carboxylates and ethyl bicyclo[2,2,2]octane-2-carboxylate have been measured and the results analysed in terms of the two limiting models for the transmission of nonconjugative substituent effects—the σ-inductive and the field models.