Steric course of the 3-hydroxy-3-methylglutaryl CoA reductase reaction
Abstract
Reduction of the hemithioacetal from coenzyme A and (±)-mevaldic acid with (4R)-[4-3H]-NADPH in the presence of 3-hydroxy-3-methylglutaryl CoA reductase from yeast gives (3R,5S)-[5-3H]-mevalonic acid.