The 2-(p-nitrophenylthio)ethyl group may be used, as an alternative to the 2-methylthioethyl group, for carboxyl-group protection in peptide synthesis and has certain advantages. The group is selectively removed after conversion into the corresponding sulphone by treatment with alkali (pH 10–10·5 at room temperature).
M. J. S. A. Amaral, J. Chem. Soc. C, 1969, 2495 DOI: 10.1039/J39690002495
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