Synthetic analogues of polynucleotides. Part III. The synthesis and polymerisation of 2′,3′-O-isopropylidene-5′-O-(3-vinylacryloyl)uridine

Abstract

2′,3′-O-Isopropylidene-5′-O-(3-vinylacryloyl)uridine has been synthesised and polymerised and copolymerised with acrylamide in aqueous solutions to give, after removal of the isopropylidene groups, water-soluble polymers. The poly-5′-O-(3-vinylacryloyl)uridine did not hybridise with denatured deoxyribonucleic acid trapped in agar but did give a hypochromic effect (5%) with denatured deoxyribonucleic acid and with polyadenylic acid in salt solution.