3-Amino-4-thiocarbamoyl-3-pyrrolines: their conversion into pyrrolo[3,4-d]pyrimidine-4-thiols

Abstract

The ready preparation of 3-amino-1,2,2-trimethyl-4-thiocarbamoyl-3-pyrroline by the action of thioacetamide on the corresponding 3-amino-4-cyanopyrroline is described. This is treated with triethyl orthoformate, acid chlorides, and thioacetamide to give the corresponding dihydropyrrolo[3,4-d]pyrimidine-4-thiols which are S- alkylated.