Carcinogenic nitrogen compounds. Part LV. Pyridobenzacridines and related heterocycles

Abstract

Bz-Aminoquinolines and Bz-aminoisoquinolines have been used successfully in Ullmann–Fetvadjian reactions with β-naphthol and paraformaldehyde to give trans-bisangular pyridobenzacridines which are isosteric with carcinogenic dibenz[a,h]acridines; the reaction could also be applied to 4-hydroxycoumarin and 3-hydroxy-thianaphthen, to give analogues of dibenz[a,h]acridine having an oxygen or a sulphur heteroatom.