An asymmetric synthesis of N-benzyl-D-aspartic acid was achieved by addition of benzylamine to N-D-α-methylbenzylmaleamic acid and hydrolysis of the resulting N1-benzyl-N2-D-α-methylbenzylasparagine with 48% hydrobromic acid. Attempts to carry out asymmetric syntheses from crotonic or maleic acids asymmetric bases were unsuccessful.
Y. Liwschitz and A. Singerman, J. Chem. Soc. C, 1966, 1200 DOI: 10.1039/J39660001200
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