The commercially important antihyperglycemic agent Rosiglitazone 1 (Avandia™) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.
X. Li, C. Abell, B. H. Warrington and M. Ladlow, Org. Biomol. Chem., 2003, 1, 4392 DOI: 10.1039/B307549D
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