Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

Aline Umuhire Juru; Zhengguo Cai; Adina Jan; Amanda E. Hargrove

doi:10.1039/D0CC00266F

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Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry†

Aline Umuhire Juru,

^a Zhengguo Cai,

^a Adina Jan^a and Amanda E. Hargrove

*^a

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* Corresponding authors

^a Department of Chemistry, Duke University, 124 Science Drive, Durham, NC 27705, USA
E-mail: amanda.hargrove@duke.edu

Abstract

This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.

This article is part of the themed collections: The Mechanics of Supramolecular Chemistry and ChemComm Advisory Board 2020

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Article information

DOI: https://doi.org/10.1039/D0CC00266F
Article type: Communication
Submitted: 10 Jan 2020
Accepted: 19 Feb 2020
First published: 19 Feb 2020

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Chem. Commun., 2020,56, 3555-3558

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Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

A. Umuhire Juru, Z. Cai, A. Jan and A. E. Hargrove, Chem. Commun., 2020, 56, 3555 DOI: 10.1039/D0CC00266F

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Chemical Communications

Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry†

Abstract

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Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry

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