Issue 32, 2024

Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review

Abstract

Baeyer–Villiger oxidation is a well-known reaction utilized for the synthesis of lactones and ester functionalities from ketones. Chiral lactones can be synthesized from chiral or racemic ketones by employing asymmetric Baeyer–Villiger oxidation. These lactones act as key intermediates in the synthesis of most of the biologically active natural products, their analogues, and derivatives. Various monooxygenases and oxidizing agents facilitate BV oxidation, providing a broad range of synthetic applications in organic chemistry. The variety of enzymatic and chemoselective Baeyer–Villiger oxidations and their substantial role in the synthesis of natural products i.e., alkaloids, polyketides, fatty acids, terpenoids, etc. (reported since 2018) have been summarized in this review article.

Graphical abstract: Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review

Article information

Article type
Review Article
Submitted
28 May 2024
Accepted
15 Jul 2024
First published
25 Jul 2024
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2024,14, 23423-23458

Baeyer–Villiger oxidation: a promising tool for the synthesis of natural products: a review

S. Fatima, A. F. Zahoor, S. G. Khan, S. A. R. Naqvi, S. M. Hussain, U. Nazeer, A. Mansha, H. Ahmad, A. R. Chaudhry and A. Irfan, RSC Adv., 2024, 14, 23423 DOI: 10.1039/D4RA03914A

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