Issue 2, 2021

Peptide-based nanomaterials for gene therapy

Abstract

Gene therapy is a novel therapeutic method and widely used for treating numerous diseases. However, the utilization of suitable materials for specifically and effectively delivering therapeutic oligonucleotides (ODNs) into a targeted site remains a great challenge. Regarding this, by possessing the capabilities of high loading rate, good stability, targeting ability and biological barrier penetration, peptide-based nanomaterials are developing rapidly and becoming a new trend in the application of gene therapy. In this review, a variety of peptide-based nanomaterials designed for gene therapy are briefly demonstrated, focusing on their main constituents in terms of three aspects: (1) small molecules, (2) nanoparticles and (3) polymers. Using peptide-based nanomaterials, a controlled gene delivery process can be achieved and directly monitored in a real-time mode. In future work, different designs of peptide-based nanomaterials need to be explored for higher gene transfection efficiency and a better therapeutic effect. In the end, some challenges and deficiencies are mentioned for bringing more attention to accelerate the research of peptide-based nanomaterials.

Graphical abstract: Peptide-based nanomaterials for gene therapy

Article information

Article type
Minireview
Submitted
27 Oct 2020
Accepted
07 Dec 2020
First published
08 Dec 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 302-310

Peptide-based nanomaterials for gene therapy

W. Zhang, Q. Chen, F. Wu, J. Dai, D. Ding, J. Wu, X. Lou and F. Xia, Nanoscale Adv., 2021, 3, 302 DOI: 10.1039/D0NA00899K

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