Ming Nie, Wenzhen Fu, Ziping Cao and Wenjun Tang
Org. Chem. Front., 2015,2, 1322-1325
DOI:
10.1039/C5QO00148J,
Research Article
An efficient asymmetric nickel-catalyzed alkylative alkyne–aldehyde cross-coupling is developed by employing a P-chiral monophosphorus ligand BI-DIME, allowing rapid access to a series of chiral tetra-substituted olefinic allylic alcohols in high yields and good to excellent ees. The three-component reactions enjoy excellent regio- and enantioselectivities, and a broad substrate scope from readily available starting materials.
