Issue 25, 2022

Visible light-assisted Ni-/Ir-catalysed atom-economic synthesis of spiro[furan-3,1′-indene] derivatives

Abstract

An atom-economic, efficient, and highly convenient construction of spiro[furan-3,1′-indene] skeletons from isocyanides and 1,5-enynes by synergistic nickel- and iridium-photocatalysis is reported. Spirocyclization was developed under practical and mild conditions, which features excellent functional group tolerance, gram-scale synthesis and representative synthetic transformations for the obtained products and broad substrate scope. Primary mechanistic studies demonstrated that the reaction proceeds through energy-transfer-mediated excitation of intermediate catalytic species.

Graphical abstract: Visible light-assisted Ni-/Ir-catalysed atom-economic synthesis of spiro[furan-3,1′-indene] derivatives

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
04 Feb 2022
Accepted
24 Feb 2022
First published
08 Mar 2022

Chem. Commun., 2022,58, 4087-4090

Visible light-assisted Ni-/Ir-catalysed atom-economic synthesis of spiro[furan-3,1′-indene] derivatives

B. S. Gore, C. Kuo and J. Wang, Chem. Commun., 2022, 58, 4087 DOI: 10.1039/D2CC00717G

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