Silver soldering of PNA:DNA duplexes: assembly of a triple duplex from bimodal PNAs with all-C on one face

Abstract

DNA:bm-PNA duplexes endowed with all-C on either the t-amide or triazole face and mixed base sequence on the other face can be welded with silver ions through C:Ag⁺:C connects to give triple duplexes in one complex. The interplay of WC and Ag⁺-mediated duplexes leads to synergistic stability effects on both duplexes and the complex.