Issue 17, 2021
From the journal:

Analyst

Crystalline sponge X-ray analysis coupled with supercritical fluid chromatography: a novel analytical platform for the rapid separation, isolation, and characterization of analytes†

Yoshimasa Taniguchi, ORCID logo *a   Mayuka Miwaa  and  Naoki Kitadaa  

* Corresponding authors

a Kirin Central Research Institute, Research & Development Division, Kirin Holdings Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan
E-mail: Yoshimasa_Taniguchi@kirin.co.jp

Abstract

Crystalline sponge (CS) based X-ray diffraction (XRD) analysis allows for the observation of the structure of an analyte, including its absolute configuration. Herein we report a powerful analytical platform for the separation, isolation, and structural elucidation of a target analyte in a seamless way by coupling supercritical fluid chromatography (SFC) with CS-based XRD analysis (SFC-CSXRD). The efficacy of this methodology is demonstrated by the rapid characterization of regio- and stereoisomers using three types of CSs with differing tolerances to the solvents used in SFC and guest-soaking.

Graphical abstract: Crystalline sponge X-ray analysis coupled with supercritical fluid chromatography: a novel analytical platform for the rapid separation, isolation, and characterization of analytes

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Article information

DOI
https://doi.org/10.1039/D1AN00948F
Article type
Communication
Submitted
27 May 2021
Accepted
21 Jul 2021
First published
21 Jul 2021

Analyst, 2021,146, 5230-5235

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Crystalline sponge X-ray analysis coupled with supercritical fluid chromatography: a novel analytical platform for the rapid separation, isolation, and characterization of analytes

Y. Taniguchi, M. Miwa and N. Kitada, Analyst, 2021, 146, 5230 DOI: 10.1039/D1AN00948F

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