Issue 8, 2019
From the journal:

Chemical Communications

Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents†

Hongxia Zhao,a   Li Tao,b   Fengmin Zhang,c   Ying Zhang,a   Yanqing Liu,*b   Hongjie Xu,a   Guowang Diao ORCID logo *a  and  Lubin Ni ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, Jiangsu, People's Republic of China
E-mail: lbni@yzu.edu.cn, gwdiao@yzu.edu.cn

b College of Medicine, Yangzhou University, Yangzhou 225001, People's Republic of China
E-mail: liuyq@yzu.edu.cn

c Testing Center, Yangzhou University, Yangzhou, Jiangsu, People's Republic of China

Abstract

Two novel sandwich-type polyoxometalates {Na0.7M5.3(H2O)2(imi)2(Himi)(SbW9O33)2}6− (M = NiII (1), CoII (2), imi = imidazole) containing a strong M–Cimi bond were synthesized by a tetragonal cluster [Na2Sb8W36O132(H2O)4]22− {Sb8W36} precursor. Compound 1 was highly cytotoxic against gastric cancer cells by arresting the cell cycle in the S-phase and inducing cell apoptosis.

Graphical abstract: Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

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Article information

DOI
https://doi.org/10.1039/C8CC07884J
Article type
Communication
Submitted
02 Oct 2018
Accepted
20 Dec 2018
First published
21 Dec 2018

Chem. Commun., 2019,55, 1096-1099

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Transition metal substituted sandwich-type polyoxometalates with a strong metal–C (imidazole) bond as anticancer agents

H. Zhao, L. Tao, F. Zhang, Y. Zhang, Y. Liu, H. Xu, G. Diao and L. Ni, Chem. Commun., 2019, 55, 1096 DOI: 10.1039/C8CC07884J

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