Retracted Article: Synthesis of diacylglycerol analogs bearing photoaffinity tags for labelling mammalian diacylglycerol kinase

Sammy Eni Eni; Meng Rowland; Michael D. Best

doi:10.1039/C4RA16730A

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Retracted Article: Synthesis of diacylglycerol analogs bearing photoaffinity tags for labelling mammalian diacylglycerol kinase†

Sammy Eni Eni,*^a Meng Rowland^a and Michael D. Best^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Tennessee, 1420 Circle Dr., Knoxville, TN 37996-1600, USA
E-mail: senieni@vols.utk.edu

Abstract

Signaling lipids such as diacylglycerol (DAG), phosphatidic acid, and the phosphatidylinositol polyphosphates are site-specific ligands for protein binding partners. Herein, we report the apotheoses of our initial approach to the development of diverse probes which are vital for understanding lipid–protein interactions. When incorporated into liposomes, these probes reduce mammalian diacylglycerol kinase's (DGK) enzymatic activity in a concentration, time, and light dependent manner.