Promising reagents for difluoroalkylation

Abstract

This review describes recent advances in difluoroalkylation reactions using different substrates. Generally speaking, RCF₂ radical is generally proposed in the mechanism of these reactions. At present, the most used difluoroalkylation reagent is RCF₂X, which can be reduced by metal, photocatalyst or bases to RCF₂ radical. Various substrates such as alkenes, alkynes, amines and so on could well be applied to these difluoroalkylation reactions.