Decreased serum zinc is an effect of ageing and not Alzheimer's disease

Alan Rembach; Dominic J. Hare; James D. Doecke; Samantha C. Burnham; Irene Volitakis; Christopher J. Fowler; Robert A. Cherny; Catriona McLean; Rudolf Grimm; Ralph Martins; David Ames; Colin L. Masters; Ashley I. Bush; Blaine R. Roberts

doi:10.1039/C4MT00060A

Decreased serum zinc is an effect of ageing and not Alzheimer's disease†

Alan Rembach,‡^a Dominic J. Hare,‡^ab James D. Doecke,^cd Samantha C. Burnham,^c Irene Volitakis,^a Christopher J. Fowler,^a Robert A. Cherny,^a Catriona McLean,^e Rudolf Grimm,^f Ralph Martins,^g David Ames,^h Colin L. Masters,^a Ashley I. Bush^a and Blaine R. Roberts*^a

Author affiliations

* Corresponding authors

^a The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia
E-mail: blaine.roberts@florey.edu.au

^b Elemental Bio-imaging Centre, University of Technology, Sydney, Broadway, New South Wales, Australia

^c CSIRO Preventative Health Flagship: Mathematics, Informatics and Statistics, Perth, Western Australia, Australia

^d The Australian e-Health Research Centre, Herston, Queensland, Australia

^e Anatomical Pathology, The Alfred Hospital, Melbourne, Victoria, Australia

^f Agilent Technologies, Santa Clara, California, USA

^g James McCusker Alzheimer's Disease Research Unit, Health Department of Western Australia, Western Australia, Australia

^h National Ageing Research Institute, Parkville, Victoria, Australia

Abstract

We examined the distribution of zinc in the periphery (erythrocytes and serum) in a large, well-characterised cohort, the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, in order to determine if there is systemic perturbation in zinc homeostasis in Alzheimer's disease (AD). We observed an age dependent decrease in serum zinc of approximately 0.4% per year. When correcting for the age dependent decline in serum zinc no significant difference between healthy controls (HC), mildly cognitively impaired (MCI) or AD subjects was observed.

This article is part of the themed collection: Zinc in the Biosciences

Metallomics

Decreased serum zinc is an effect of ageing and not Alzheimer's disease†

Abstract

Supplementary files

Article information

Download Citation

Author version available

Search articles by author

Spotlight

Advertisements