Issue 6, 2014

Cationic gold(i)-catalyzed enantioselective hydroalkylation of unactivated alkenes: influence of the chloride scavenger on the stereoselectivity

Abstract

Enantioselective intramolecular additions of β-ketoamides to unactivated alkenes have been accomplished by means of gold catalysis. Chiral LAuCl complexes have been activated by various Lewis acids (Cu, Ag, Ga, In, Si, Bi etc.). The influence of these activators on the stereoselectivity has been studied.

Graphical abstract: Cationic gold(i)-catalyzed enantioselective hydroalkylation of unactivated alkenes: influence of the chloride scavenger on the stereoselectivity

Supplementary files

Article information

Article type
Research Article
Submitted
17 Apr 2014
Accepted
30 Apr 2014
First published
05 Mai 2014

Org. Chem. Front., 2014,1, 608-613

Cationic gold(I)-catalyzed enantioselective hydroalkylation of unactivated alkenes: influence of the chloride scavenger on the stereoselectivity

W. Fang, M. Presset, A. Guérinot, C. Bour, S. Bezzenine-Lafollée and V. Gandon, Org. Chem. Front., 2014, 1, 608 DOI: 10.1039/C4QO00112E

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